Illinois State University1, Normal, IL 61790 ISU2, Normal, IL 61790
Ongoing studies indicate that carbaporphyrin ketals offer a great promise in the treatment of the parasitic disease Leishmaniasis. Recently carbaporphyrin ketals were found to induce reactive oxygen species (ROS) in Leishmania tarentolae in vitro.2 As a part of a continuing effort to indentify the mechanism of carbaporphyrin ketal inhibition, we have tested cultures of Leishmania tarentolae with and without addition of dimethyl carbaporphyrin ketal towards the induction of reactive nitrogen species, such as nitric oxide, using confocal fluorescence microscopy and electron paramagnetic resonance (EPR). The induction of nitric oxide by carbaporphyrin ketal in L. tarentolae is described in this presentation.
[Abstract (DOC)]