S. Illinois Univ. Edwardsville, Biological Sciences, Edwardsville, IL 62026
Our laboratory has long been interested in drug effects on murine immune response. Antibiotics such as Cubicin, Tigecycline, Dalbavancin, Ticarcillin, Zythromax, Clindamycin and others have mostly been found to stimulate macrophage and often neutrophil killing of yeast targets. T cell function was also boosted as measured with an ear-thickness assay to determine the delayed type hypersensitivity (DTH) response to the sensitizing chemical DNFB. We are currently planning to study some of the mechanisms that may be responsible for killing enhancement by immune cells such as changes in cytokines produced or possible changes in levels of nitrous oxide, digestive enzymes and toxic oxygen. This work has been funded in part by the Max Baer Heart Fund, Fraternal Order of Eagles. M.H. and S.C. are LS-AMP Research Scholars, NSF/HRD 094024.
[Abstract (DOCX)]